Effect of Paractamol in Closing of PDA in Preterm Babies

Abstract

Objective: We tried to collect no of preterm babies less than 32 weeks less than 1500gram admitted in NICU from 1-1-2020 till the end of 31- 12-2021 And we want to see the effects of paractamol in form of closing of ducts arteriosus in preterm babies, we used gestation age between 24 weeks till 32 weeks delivery at this period.

Methods: We used paractamol in a dose of 15mg/kg/dose for three days in all preterm babies less than 1500 grams and we did Echocardiogram if PDA is present and affected the hemodynamic and stability of the babies, for example, the babies on a mechanical ventilator, received two doses of servants had hypotension and had large to moderate PDA we gave them paractamol 15mg/kg every 6 hours then we repeated Echocardiogram if still, PDA is present we gave them second course 15mg/kg/dose for 2 days.

We rolled in 400 babies preterm delivered from 1-1-2020 till the end of 31-12-202we did a retrospective study to collect the data from files we saw the response of the drug in form of closing PDA and only one baby had surgery in form of PDA ligation.

Inclusion Criteria: Preterm less than 32 weeks or less than 1500gram. Preterm had hypotension and need a high setting of the ventilator. Any preterm less than 32 weeks and echocardiogram show PDA. Any preterm babies whose mothers have not received antenatal steroids. Any congenital anomalies have not affected the life.

Excluding Criteria: Multiple congenital anomalies. Preterm babies who died before roll in the study. Preterm babies who died within 48 hours. Any preterm had coagulopathy. Any preterm had renal failure.